HPE NIC 100GB 2-Port QSFP28 E810

Data centers and high-performance computing clusters demand network hardware that can keep pace with massive east-west traffic and latency-sensitive workloads. The HPE P22201-001 network interface card steps into that role, equipping servers with dual 100 Gigabit Ethernet QSFP28 ports driven by the Intel E810 controller. It is a full-height, half-length PCIe 4.0 x16 card built for virtualization, storage offload, and software-defined networking.

Key specifications

• Dual QSFP28 ports, each supporting 100GbE (100GBASE-SR4/LR4 via transceivers)
• PCI Express 4.0 x16 host interface for full bandwidth utilization
• Intel Ethernet Controller E810-XXVDA2 with RDMA (RoCEv2, iWARP) and NVMe-oF offloads
• SR-IOV with up to 256 virtual functions, VMDq, VXLAN, NVGRE, GENEVE
• Jumbo frame support up to 9.5 KB, Data Center Bridging (PFC, ETS, DCBX)
• IEEE 1588 PTP, PXE/iSCSI/FCoE boot, typical power 18W
• Supported OS: Windows Server, RHEL, SLES, Ubuntu, VMware ESXi

Why choose it

This adapter removes network bottlenecks in dense virtualized environments. With hardware offloads for overlay networks and storage protocols, it frees CPU cycles for application workloads. The E810 chipset brings Adaptive Virtual Function technology, simplifying driver management across many VMs. Dual 100GbE ports provide redundancy or link aggregation for mission-critical services.

Ideal use cases

• Hyper-converged infrastructure and software-defined storage (vSAN, Ceph)
• High-frequency trading and financial modeling where microsecond latency matters
• AI/ML training clusters requiring high-throughput, low-latency interconnects
• Virtualized data centers running thousands of containers or VMs per host
• NVMe-oF target or initiator for shared flash storage fabrics

Good to know

The card is a standard full-height, half-length PCIe add-in card and includes both full-height and low-profile mounting brackets. QSFP28 transceivers and DAC/AOC cables are sold separately. HPE qualifies this adapter for ProLiant and Synergy servers; check the server QuickSpecs for exact compatibility. The Intel E810 supports both 100GbE and 25GbE per port with appropriate optics, offering investment protection.